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Characteristics underlying development of multiple lesions in superficial Barrett's adenocarcinoma and long-term outcomes after their endoscopic resection
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H. Kikuchi1,
T. Koike1,
T. Shimosegawa1 |
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1Division of Gastroenterology Tohoku University Graduate School of Medicine |
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| Objective; The objective of this study was to clarify the characteristics underlying development of multiple lesions in superficial Barrett's adenocarcinoma (SBA) and long-term outcomes of SBA after endoscopic resection (ER). Methods; We retrospectively compared patients' backgrounds and endoscopic findings of 52 single SBA patients with that of 6 multiple SBA patients. In addition, we evaluated the long-term outcomes of ER for 38 patients with SBA and 205 patients with superficial esophageal squamous cell carcinoma (SESCC). Results; LSBE was more frequently seen among patients with multiple SBA than patients with single SBA (50.0% vs 12.1%, p<0.05). The existence of lesions in the 0 to 2 o'clock location was significantly higher in patients with single SBA than patients with multiple SBA (78.6% vs 27.3%, p<0.01). The median observation period after ER was 46.4 months (range, 6-115 months) for the SBA and 43.3 months (range, 6-130 months) for the SESCC. The cumulative 5-year overall survival rates and disease-free survival rates did not differ between SBA and SESCC. The cumulative 5-year recurrence rates of patient with SBA were significantly lower than that of patients with SESCC (2.6% vs 14.6%, p<0.05). Conclusion; LSBE was a risk factor for multiple development of SBA. The recurrence rate after ER was lower in patients with SBA than in patients with SESCC. |
Index Term 1: Barrett's adenocarcinoma
Index Term 2: long-term outcomes after endoscopic resection |
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