Japan Digestive Disease Week 2016
International Poster Session(JDDW)
November 4 (Fri.), 15:20–16:16, Room 16 (Kobe International Exhibition Hall No. 2 Building Hall (North) Digital Poster Session)
IP-42_E
Quantitative evaluation of 18F-FDG PET/CT for colorectal cancer screening
- 1
- Department of Gastroenterology, Hiroshima City Asa Citizens Hospital
BACKGROUND: Positron emission tomography/computed tomography (PET/CT) is widely applied for colorectal cancer (CRC) diagnosis. However, few previous studies have analyzed the association between standardized uptake value (SUV) and clinicopathological characteristics of CRC.
METHODS: One-hundred and seventy-seven, consecutive, endoscopically or surgically treated CRC patients (71 men; mean age, 69 years) who underwent PET/CT and colonoscopy at our hospital between January 2014 and December 2015 were enrolled. Tumoral SUVmax was investigated. SUVmax >10 was considered high. Relationships between high SUV and clinicopathological characteristics were examined, including age, sex, location, size, macroscopic type, histological type, invasion depth, budding grade, and the presence of lymph node metastasis.
RESULTS: One-hundred and sixteen (66%) CRCs had high SUV. Clinicopathological characteristics associated with high SUV were a sigmoid colon or rectal location (P = 0.0251), tumor diameter >3 cm (P < 0.0001), macroscopic type 1, 2, or 3 (P < 0.0001), undifferentiated histology (P = 0.0002), invasion deeper than the muscularis propria (P < 0.0001), budding grade 2 or 3 (P < 0.0001), and the presence of lymph node metastasis (P < 0.0001). On multivariate analysis, a sigmoid colon or rectal location (odds ratio [OR], 3.56; 95% confidence interval [CI], 1.53-8.81) and a tumor diameter >3 cm (OR, 5.71; 95% CI, 2.13-16.2) were independent factors for high SUV.
CONCLUSION: As a screening tool, PET/CT provided useful information about CRC.
METHODS: One-hundred and seventy-seven, consecutive, endoscopically or surgically treated CRC patients (71 men; mean age, 69 years) who underwent PET/CT and colonoscopy at our hospital between January 2014 and December 2015 were enrolled. Tumoral SUVmax was investigated. SUVmax >10 was considered high. Relationships between high SUV and clinicopathological characteristics were examined, including age, sex, location, size, macroscopic type, histological type, invasion depth, budding grade, and the presence of lymph node metastasis.
RESULTS: One-hundred and sixteen (66%) CRCs had high SUV. Clinicopathological characteristics associated with high SUV were a sigmoid colon or rectal location (P = 0.0251), tumor diameter >3 cm (P < 0.0001), macroscopic type 1, 2, or 3 (P < 0.0001), undifferentiated histology (P = 0.0002), invasion deeper than the muscularis propria (P < 0.0001), budding grade 2 or 3 (P < 0.0001), and the presence of lymph node metastasis (P < 0.0001). On multivariate analysis, a sigmoid colon or rectal location (odds ratio [OR], 3.56; 95% confidence interval [CI], 1.53-8.81) and a tumor diameter >3 cm (OR, 5.71; 95% CI, 2.13-16.2) were independent factors for high SUV.
CONCLUSION: As a screening tool, PET/CT provided useful information about CRC.
- Index Term 1: Colorectal cancer
- Index Term 2: PET/CT