POSITIVE CORRELATION BETWEEN DEGREE OF LIVER CIRRHOSIS AND N TERMINAL PRO BRAIN NATRIURETIC PEPTIDE (NTproBNP) IN LIVER CIRRHOSIS PATIENTS

Liver Cirrhosis (LC) is a chronic disease characterized by damage of liver parenchyme with wide fibrosis and nodules formation. One of LC complications is Cirrhotic Cardiomyopathy (CC), diagnosed when there are more than one of the following signs: Diastolic Dysfunction (DD), Systolic Dysfunction (SD), enlargement of the cardiac chamber, electrophysiology dysfunction, and increasing of natriuretic peptide such as NT-proBNP. This study was to determine the correlation between degree of liver cirrhosis and increasing of the NT-proBNPCross-sectional analytic study was performed. Degree of liver cirrhosis was determined by Child Turcotte Pugh (CTP) criteria and NT-proBNP was examined by ECLIA. Subjects with other disorders causing increase of NT-proBNP were excluded. We used Spearman's correlation test. From 72 subjects, 79,2% men. Patients with CTP A were 9 (12,5%), B 19 (26,4%) and C 44 (61,19%). Median of NT-proBNP in CTP A was 112 (5-180) pg/ml, B 130 (11,7-860) pg/ml, C 315 (86-1980) pg/ml. There was a possitive correlation between degree of LC and NT-proBNP (r=0.686 p=0.000).In conclusion, LC and NT-proBNP was positively correlated.