Blue-laser imaging compared to white light imaging colonoscopy for detection of colonic adenomas: a randomized tandem pilot tria

Study aims: The aim of the present study was to determine whether blue-laser imaging (BLI) reduced mis-detection of colon adenomatous lesions compared to regular white-light imaging (WLI).
Patients and methods: This was a prospective randomized study of patients undergoing screening and/or surveillance colonoscopy at our medical school, Japan. One hundred and twenty-seven patients were randomized to tandem colonoscopy with BLI followed by WLI (BLI-WLI group) or WLI followed by WLI (WLI-WLI group). The main outcome measure was mis-detection rate of colon adenomatous lesions.
Results: The proportion of patients with adenomatous lesions was 62.5% (40/64) in the BLI-WLI group and 63.5% (40/63) in the WLI-WLI group. The total number of adenomatous lesions detected in the primary inspection of the BLI-WLI and WIL-WLI groups was 179 and 108, respectively, compared with 182 and 120 in the secondary inspection. The mis-detection rate in the BLI-WLI group was (1.6%), which was significantly less than in the WLI-WLI group (10.0%, P = 0.0014).
Conclusions: Mis-detection of colon adenomatous lesions was less in the BLI-WLI group compared to the WLI-WLI group, suggesting that BLI is applicable for routine colonoscopy