| International Session (Symposium) 5 (JSGE・JGES) |
| Fri. November 2nd 9:40 - 12:00 Room 13: Kobe International Conference Center International Conference Room |
| Esophageal motor activity and wall distensibility before and after endoscopic resection | |||
| Hironobu Mikami1, Norihisa Ishimura1, Yoshikazu Kinoshita1 | |||
| 1Department of Gastroenterology and Hepatology, Shimane University School of Medicine | |||
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| Background and Aim: Following a wide-ranging endoscopic treatment for esophageal neoplasms, dysphagia often appears irrespective of scarring stenosis on the resection site. However, esophageal motor activity during the treatment remain to be fully elucidated. We aimed to investigate the influence of endoscopic resection on esophageal motility and wall distensibility obtained before and after resection. Methods: We enrolled 15 patients with esophageal neoplasms treated by endoscopic resection from June 2016 to October 2017. They were divided into 3 groups (1; endoscopic mucosal resection, 2; sub-circumferential, and 3; circumferential resection). Esophageal motility was evaluated before resection, 1 week after resection, and after re-epithelialization using high resolution manometry system (Starlet®). Esophageal wall distensibility after re-epithelialization was investigated by functional lumen imaging system (EndoFLIP®). Results: Most of the cases showed normal peristalsis before resection, while attenuation or disappearance of peristaltic wave on the resection site was observed in all cases 1 week after resection. The distal contractile integral (DCI) value was significantly decreased with dysphagia in group 2 and 3. Interestingly, peristalsis and DCI value was recovered in all cases after re-epithelization. The resection range was associated with the wall distensibility, and dysphagia persisted in one patient with the lowest distensibility. Conclusions: Esophageal motility following endoscopic resection is temporarily reduced regardless of the resection method, though recovers after re-epithelialization. Furthermore, dysphagia after re-epithelialization may be due to the decrease of esophageal wall distensibility. |
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Index Term 1: manometry Index Term 2: dysphagia |
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