| International Session（Symposium）3(JSGS・JSGE・JSH・JSGCS) |
| Fri. November 22nd 14:00 - 16:30 Room 2: Kobe International Exhibition Hall No.2 Building Hall (South) |
| Risk assessment of metachronous SCC after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of ADH1B and ALDH2 | |||
| Satoshi Abiko1,2, Yuichi Shimizu3, Naoya Sakamoto2 | |||
| 1Department of Internal Medicine, Kushiro Rosai Hospital, 2Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, 3Division of Endoscopy, Hokkaido University Hospital | |||
|
|||
|
|||
| Background Metachronous multiple squamous cell carcinoma (SCC) of the esophagus (ESCC) and SCC of the head and neck (HNSCC) are commonly observed in patients who have undergone endoscopic resection (ER) for ESCC. Methods We studied 158 patients who underwent ER. We evaluated the risk for developing metachronous SCC following ER for ESCC based on the genetic polymorphisms for alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) as well as alcohol consumption and smoking habits. Results Multivariate analyses revealed that inactive heterozygous ALDH2 (hazard ratio [HR] = 2.25) and alcohol consumption after ER (HR = 1.94) were independently associated with the risk of secondary SCC. When analysis was performed with secondary SCC divided into ESCC and HNSCC, inactive heterozygous ALDH2 (HR = 2.77) and alcohol consumption after ER (HR = 2.04) were identified as risk factors for ESCC and slow-metabolizing ADH1B (HR = 3.33) and alcohol consumption after ER (HR = 2.04) were risk factors for HNSCC. Conclusions Inactive heterozygous ALDH2 is a risk factor for secondary SCC and ESCC, and slow-metabolizing ADH1B is a risk factor for secondary HNSCC. Further studies for personalized surveillance are required for the genetic polymorphisms. |
|||
|
Index Term 1: Aldehyde dehydrogenase2 Index Term 2: Esophageal cancer |
|||
| Page Top | |||