| International Session（Symposium）3(JSGS・JSGE・JSH・JSGCS) |
| Fri. November 22nd 14:00 - 16:30 Room 2: Kobe International Exhibition Hall No.2 Building Hall (South) |
Non-invasive diagnostic biomarker for gastric cancer using urinary microRNAs
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| Hiroyasu Iwasaki1, Takaya Shimura1, Hiromi Kataoka1 | |||
| 1Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Science | |||
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| Background: No non-invasive screening biomarkers have not been established for gastric cancer (GC). The aim of this study is to develop urinary miRNA biomarker for GC detection. Methods: Among 372 urine samples, age- and sex-matched 306 participants (153 pairs from GC patients and healthy controls [HCs]) were randomly classified into 3 groups: the discovery cohort (4 pairs); the training cohort (95 pairs); the validation cohort (54 pairs). Results: First, we identified 22 urinary miRNAs with significantly aberrant expressions between 2 groups in the discovery cohort. The multivariate analysis showed that Helicobacter pylori (H. pylori) status and urinary levels of miR-6807-5p and miR-6856-5p were significantly independent biomarkers for diagnosis of GC, in the training cohort. The diagnostic panel combining these miRNAs and H. pylori status distinguished between the HCs and GC samples with an area under the curve (AUC) = 0.736. In the validation cohort, urinary miR-6807-5p and miR-6856-5p showed significantly higher expression levels in the GC group, and the established combination biomarker panel also showed excellent performance (AUC = 0.885). Conclusion: This urinary biomarker panel is a novel, non-invasive biomarker for the early detection of gastric cancer. |
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Index Term 1: gastric cancer Index Term 2: urinary microRNA |
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