| International Session（Symposium）4(JSGE・JGES) |
| Fri. November 22nd 9:30 - 12:00 Room 11: Portopia Hotel South Wing Topaz |
| Early-life stress induced gastric hypersensitivity in adult rats | |||
| Takashi Kondo1, Shaoqi Duan1,2, Hiroto Miwa1 | |||
| 1Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 2Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences | |||
|
|||
|
|||
| Background & Aims: Maternal separation (MS) can be used as a stress model of early-life adversity for rodents, which is thought to be associated with long-lasting alterations of the neural system, inducing visceral hypersensitivity. This study aims to focus on gastric hypersensitivity caused by MS stress and to establish a rat model of functional dyspepsia (FD) with gastric hypersensitivity. Method: Both male and female newborn Sprague Dawley rats were randomly divided into an MS group and a control group. The MS rats were separated individually for 2 hours a day, from postnatal day 1 to day 10. Visceromotor responses to gastric distention (GD) were performed when the rats reached 8 weeks of ageand recorded by quantifying the activity on electromyography (EMG) recorded with electrodes implanted in the acromiotrapezius muscle. Result: There was no significant difference in body weight between MS and control rats. GD caused an intensity-dependent increase in EMG activity in both groups. The EMG responses significantly increased in the MS rats (n=19)at 60 mmHg (P< 0.01)and 80 mmHg (P< 0.001)compared to the control rats (n=24). Conclusion: Maternal separation stresscould induce a potential rat model of gastric hypersensitivity of FD, which could be used to research the mechanisms of FD. |
|||
|
Index Term 1: Functional dyspepsia Index Term 2: Gastric hypersensitivity |
|||
| Page Top | |||