| International Session（Symposium）4(JSGE・JGES) |
| Fri. November 22nd 9:30 - 12:00 Room 11: Portopia Hotel South Wing Topaz |
| Efficacy of the slow nutrient drink test as minimally invasive method to reproduce symptoms in Japanese patients with functional dyspepsia | |||
| Tatsuhiro Masaoka1, Hisako Kameyama1, Takanori Kanai1 | |||
| 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine | |||
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| Background: One of the pathophysiology of FD is impaired accommodation. Tack et al previously proposed slow nutrient drinking test as minimally invasive method to evaluate accommodation (Gut 2003). We aimed to evaluate efficacy of slow nutrient drinking test for Japanese patients with FD. Methods: 26 healthy controls and 16 patients with FD were enrolled. An infusion pump supplied 1.5kcal/ml liquid meal at a rate of 15 ml/min. Participants were asked to score hunger, satiation and symptoms (bloating, fullness, nausea, belching, cramps and epigastric pain) at 5minutes intervals using a visual analogue scale. When they cannot continue due to severe symptom or reached 50 minutes, the test was stopped. This study was approved by the Ethics Committee in our institution. Results: The test ending time in patients with FD was significantly shorter than healthy volunteers. ROC analysis showed that 30 minutes was the best cut-off value to detect patients with FD. Except pain and cramps, other symptom severity score between controls and FD patients was continuously different. Multivariate analysis revealed contribution of presence of postprandial distress syndrome on short ending time. Conclusion: Efficacy of the 30 min slow nutrient drink test as minimally invasive method to reproduce symptoms in Japanese patients with FD was suggested. |
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Index Term 1: Functional Dyspepsia Index Term 2: Drink test |
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