| International Session（Symposium）4(JSGE・JGES) |
| Fri. November 22nd 9:30 - 12:00 Room 11: Portopia Hotel South Wing Topaz |
| Timing and predictors of recurrence of dyspepsia symptoms after cessation of acotiamide therapy for functional dyspepsia: A long-term observational study | |||
| Satoshi Shinozaki1, Hiroyuki Osawa2, Alan Kawarai Lefor3 | |||
| 1Shinozaki Medical Clinic, 2Department of Medicine, Division of Gastroenterology, Jichi Medical University, 3Department of Surgery, Jichi Medical University | |||
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| Background/Aims: The long-term outcomes of patients after cessation of acotiamide therapy in patients with functional dyspepsia remains unclear. The aim of this study is to investigate the timing and predictors of recurrence of dyspepsia symptoms after cessation of acotiamide therapy for functional dyspepsia. Methods: Seventy patients treated with acotiamide for functional dyspepsia who then ceased treatment were enrolled. Changes in dyspepsia symptoms were evaluated using the Izumo scale, a self-reporting questionnaire of abdominal symptom-related quality of life. Patients were sub-classified into epigastric pain, postprandial distress and overlapped types. Results: The mean follow-up after cessation of acotiamide was 1.9 years. After cessation of acotiamide, 39 patients (56%) had recurrence. Kaplan-Meier analysis revealed a recurrence-free rate of 51% at one year. Predictors of recurrence evaluated with a Cox proportional hazards model showed that overlapped type dyspepsia and consultation with the treating physician before cessation were identified as significant positive and negative predictors, respectively (p<0.05). The resumption of acotiamide significantly decreased the score for dyspepsia symptoms at one month. Conclusions: Dyspepsia symptoms recur about one year after cessation of acotiamide therapy. Patients with overlapped type dyspepsia should be carefully followed after cessation. Patients should consult their treating physician before stopping acotiamide. |
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Index Term 1: acotiamide Index Term 2: dyspepsia |
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