| International Session（Symposium）7(JSGS・JSGE・JGES) |
| Sat. November 23rd 10:00 - 12:00 Room 1: Kobe International Exhibition Hall No.2 Building Hall (North) |
| The effects of loss of skeletal muscle volume on patients with Crohn’s disease underwent bowel resection | |||
| Shuhei Hosomi1, Naoko Sugita1, Yasuhiro Fujiwara1 | |||
| 1Department of Gastroenterology, Osaka City University Graduate School of Medicine | |||
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| Background: Sarcopenia can be related to not only orthopedic disease but also malignant tumor and liver disease and has been drawing attention in recent years. Inflammatory bowel disease could also cause secondary sarcopenia. This study investigated the effects of loss of skeletal muscle volume on patients with Crohn’s disease (CD) underwent bowel resection. Method: 101 patients with CD underwent bowel resection and abdominal computed tomography images within 30 days before operation between July 2007 and December 2016 were retrospectively enrolled. Sarcopenia was defined as L3 skeletal muscle index (SMI) less than 42 cm2/m2 for men and 38 cm2/m2 for women. We analyzed predictive factors for postoperative complication and CD recurrence. Results: The patients included 80 men and 21 women. Indications for operation were 54 for stenosis, 47 for perforation or abscess. 72.3% (54 men and 19 women) of the patients were low SMI. There were no predictive factors for postoperative complication. Biologics use for maintenance (adjusted HR = 2.400; 95%CI: 1.006–5.726; p = 0.048) and elemental diet (ED) intake (adjusted HR = 2.692; 95%CI: 1.337–5.421; p = 0.005) were statistically related with CD recurrence after bowel resection. Conclusion: The prevalence of sarcopenia is high in patients with CD underwent bowel resection. Biologics use and ED intake, but not low SMI, were independent protective factors for postoperative recurrence. |
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Index Term 1: Sarcopenia Index Term 2: Crohn's disease |
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