| International Session（Symposium）8(JGES・JSGE・JSGS・JSGCS) |
| Sat. November 23rd 14:30 - 17:00 Room 11: Portopia Hotel South Wing Topaz |
Pan-enteroscopic survey for post allogeneic hematopietic stem cell transplantation by using colon capsule endoscopy
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| Ryoichi Miyanaga1, Naoki Hosoe2, Haruhiko Ogata2 | |||
| 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 2Center for Diagnostic and Therapeutic Endoscopy, Keio University | |||
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| Background and study aim: Graft-versus-host disease (GVHD) and cytomegalovirus (CMV) infection occur in the whole gastorointestinal (GI) tract in post allogeneic haematopoietic stem cell transplantation (allo-HSCT). Colon capsule endoscopy (CCE) can obtain through GI tract images non-invasively. The study aim was to evaluate the efficacy of pan-enteric survey with CCE for post allo-HSCT. Patients and methods: This was a prospective observational study. CCE using PillCam COLON2® was performed for pan-enteroscopy on the day 21-28 post allo-HSCT. If CCE images showed suspicious of GVHD and/or CMV infection, or the patients had abdominal symptoms, conventional endoscopy and/or enteroscopy and histological examination were performed. If CCE did not show abnormal findings nor GI symptoms until the day 60, the patient was defined as free of GVHD and/or CMV infection. Results: 30 patients were scheduled for enrollment. All CCE reached colon. The per site sensitivity, specificity and accuracy of CCE findings compared with endoscopy and/or enteroscopy were 73%, 99% and 90%, respectively. The per patient sensitivity, specificity and accuracy of CCE for any findings were 58%, 86% and 73%, respectively. In CCE finding positive group, there was a tendency to be diagnosed as histopathology GVHD and/or CMV infection. Conclusions: Pan-enteric survey using CCE was applicable for post allo-HSCT. |
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Index Term 1: Colon Capsule endoscopy Index Term 2: Graft-versus-host disease |
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