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Colon capsule endoscopy is a useful tool to assess mucosal healing in patients with ulcerative colitis in clinical remission
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Satoshi Osawa1,
Ryosuke Takano2,
Ken Sugimoto2 |
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1Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, 2First Department of Medicine, Hamamatsu University School of Medicine |
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| Aim: To examine whether second generation of colon capsule endoscopy (CCE-2) is acceptable for assessing the severity of mucosal inflammation and evaluating mucosal healing using CCE-2 predicts outcome in ulcerative colitis (UC) patients, especially in clinical remission. Methods: A total of 55 examinations in UC patients in clinical remission (Rachmilewitz index ≤4) were enrolled. The rate of total colon observation was evaluated. Severity of mucosal inflammation was assessed according to the Mayo endoscopic subscore (MES) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS). Relapse-free survival was assessed. Acceptability of CCE-2 was assessed using a questionnaire survey. Results: The rate of total colon observation within its battery life was 96.4%. The rate of mucosal healing (MES 0,1) assessed by CCE-2 was 80.0%. The relapse-free survival rate was significantly higher in MES 0,1 than in MES 2,3 (p<0.01), and in UCEIS 0–3 than in UCEIS 4–8 (p<0.01), whereas there was no significant difference between clinical activity index (CAI) 0 and CAI 1–4. A questionnaire survey revealed an overall acceptability of CCE. Conclusions: Our preparation regimen for CCE-2 could attain a high rate of total colon observation and high acceptability, and that assessment of endoscopic activity by CCE-2 using MES and UCEIS was able to predict outcome. |
Index Term 1: colon capsule endoscopy
Index Term 2: ulcerative colitis
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