| Aims: To determine the usefulness of FICE for CCE interpretation. Methods: This prospective study included optical colonoscopy (CS) within four months after CCE. One endoscopist reviewed white light images (CCE-WL), and the other reviewed FICE images (CCE-FICE). Based on CS findings, detectability of CRTs between CCE-WL and CCE-FICE was compared. Next, their FICE images were classified into three categories: FICE-B: whole blue, FICE-M: mixed blue and white, FICE-W: whole white. The relationship between the FICE classification and the pathological diagnosis was retrospectively evaluated. Results: Forty-nine patients with CRTs were prospectively enrolled. The sensitivity and specificity of CRTs ≥6 mm and ≥10 mm per patient was not significant different between CCE-WL and CCE-FICE, but the sensitivity per lesion with CCE-WL and CCE-FICE was 47% and 71%, respectively (P=0.00002). According to the FICE classification, all adenocarcinomas showed FICE-B and 76% of tubular adenoma showed FICE-B or FICE-M, while 50% of SSA/P or HP showed FICE-W (P=0.01). The sensitivity and specificity of combination of FICE-B/FICE-M was 100% and 35% for adenocarcinoma, 76% and 47% for tubular adenoma, respectively, while sensitivity and specificity of FICE-W were 50%, 77% for SSA/P and HP, respectively. Conclusions: CCE-FICE could not only elevate diagnostic accuracy but also estimate the pathological diagnosis of CRTs. |
