| International Session（Workshop）1(JGES・JSGE・JSGS・JSGCS) |
| Sat. November 23rd 9:30 - 12:00 Room 11: Portopia Hotel South Wing Topaz |
Pre-clinical animal test using novel hydrophilic plastic stent system in swine models
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| Jae Keun Park1, Kyu Taek Lee2, Joo Kyung Park2 | |||
| 1Digestive Disease Center and Research Institute, Department of Internal Medicine, SoonChunHyang University School of Medicine, 2Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine | |||
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| BACKGROUND: Plastic stent(PS) is easier to apply and to remove than metal stent in biliary obstructive diseases. However, there are several limitations including insufficient luminal diameter and short patency period. Many methods have been studied to improve the disadvantages. The study aim is to evaluate the effect of advanced hydrophilic PS using novel surface modification technique via vacuum plasma in swine models. METHODS: Six in vivo swine models were made by using intraductal radiofrequency ablation(RFA). We compared biofilm and patency between Polyethylene PSs with hydrophilic characteristic(PS+HC) and PSs without hydrophilic characteristic(PS-HC). Histologic evaluation of surrounding bile duct was done at 1, 3, and 5 months. RESULT: PS+HC showed less biofilm formation and better patency rates at 1 and 3 months than PS-HC(p<0.05). There was no statistically significant difference of biofilm formation and patency rate between PS+HC and PS-HC at 5 months. However, total occlusion was noticed on the PS-HC at 5 months. Histologic inflammation scores were significantly lower in PS+HC than PS-HC at 5 months(p<0.05). CONCLUSION: PS+HC may reduce the biofilm formation and lumen stenosis. This may result less damage to surrounding tissues during PS implantation period and PS+HC could be safer than PS-HC. |
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Index Term 1: Hydrophilic Plastic Stent Index Term 2: Surface Modification Technique |
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