| International Session（Symposium）1(JSH・JSGE・JSGCS) |
| Thu. November 5th 9:00 - 11:20 Room 5: Portopia Hotel South Wing Ohwada A |
Significance of T-cell profile analysis in NAFLD patients.
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| Takuya Seike1, Eishiro Mizukoshi1, Shuichi Kaneko1 | |||
| 1Department of Gastroenterology, Kanazawa University | |||
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| 【Background】Understanding the role of T-cell profiles in non-alcoholic fatty liver disease (NAFLD) patients and identifying factors that affect its function will enable the establishment of non-invasive diagnostics and the development of novel therapeutics. 【Method】We analyzed the differences in T-cell profiles of peripheral blood mononuclear cells (PBMCs) between 40 NAFLD patients and 5 healthy volunteers (HVs), and their relationship with liver fibrosis stage or progression. Moreover, we analyzed the relationship between T-cell profiles and fatty acid compositions in vivo, and changes in T-cell profiles after treatment with fatty acids in vitro. 【Result】T-cell profiles of NAFLD patients were different from those of HVs. The frequencies of Th2 or Th17 cells were significantly increased in NAFLD patients compared to those in HVs. And, the CD25+CD45+CD4+ T-cell frequency was increased in NAFLD patients with high liver fibrosis stage and progression. Despite such a state of immune activation, the PD1+CD4+ T-cell frequency was decreased in the same patients group. The PD1+CD4+ T-cell frequency had a significantly negative correlation with the serum fatty acid composition ratio C16:1n7/C16:0. The rate of frequency change of PD1+CD4+T-cell was significantly different between C16:0 and C16:1n7 and decreased by artificially increasing the C16:1n7/C16:0 ratio. 【Conclusion】T cell profile in NAFLD patients can be affected by fatty acids. Elucidation of its molecular mechanism may enable the development of new therapeutics for NAFLD patients. |
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Index Term 1: NASH Index Term 2: T-cell |
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