| International Session（Symposium）1(JSH・JSGE・JSGCS) |
| Thu. November 5th 9:00 - 11:20 Room 5: Portopia Hotel South Wing Ohwada A |
| Clinical and Anthropometric Characteristics of Non-obese NAFLD Patients | |||
| Takashi Shida1, Natsumi Oshida1, Hideo Suzuki1 | |||
| 1Faculty of Medicine, University of Tsukuba | |||
|
|||
|
|||
| Background/Objective Relatively many non-obese patients develop NAFLD. However, the pathophysiology of NAFLD has not been completely elucidated. Methods The study included 404 patients with NAFLD. The NAFLD patients were divided into 3 groups as follows: 107 non-obese (BMI<25 kg/m2), 178 obese (≥25 to <30 kg/m2), and 64 severe obese (≥30 kg/m2), and compared with 253 patients without obesity and NAFLD (non-NAFLD group). Results The non-obese group accounted for 26% of the men and 28% of the women. The skeletal muscle mass of the non-obese group was lower than that of the obese groups and equal to that of the patients in the non-NAFLD group. However, a remarkable difference in muscle steatosis was observed. Knee extension strength decreased. Compared with the obese groups, the non-obese group had a smaller visceral fat area, which was >100 cm2 in 59% of the men and 44% of the women. On the FAST score, 8.8% of men and 32.6% of women in the non-obese NAFLD group were assessed as having NASH. Multiple regression analysis revealed that the factors contributing towards increased liver fat accumulation in the non-obese patients were visceral fat area, HbA1c, myostatin, and leptin levels. Conclusions In the non-obese NAFLD patients, in addition to the increase in visceral fat, a decrease in the muscle mass and strength, deterioration of muscle composition (sarcopenia), and associated impaired glucose tolerance were considered important factors. |
|||
|
Index Term 1: non-obese NAFLD Index Term 2: sarcopenia |
|||
| Page Top | |||