Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
[Aim] We analyzed the efficacy of EUS for early gastric cancer (EGC) cases for which optical in-depth diagnosis was difficult to achieve through conventional upper gastrointestinal endoscopy. [Methods]
A total of 58 patients with 59 lesions of EGCs who underwent pre-treatment EUS and following endoscopic or surgical resection were included. Each cancer was screened by EUS, which mainly showed obvious elevation (27.1%), followed by ulceration (23.7%). The capability of EUS to enable in-depth diagnosis and guide treatment strategies were discussed. [Results] The accuracy rate of EUS for mucosal cancer (T1a) was higher than that for submucosal cancer (T1b), (90.5% vs. 50%, P < 0.01). Among the 38 lesions diagnosed as T1b by EUS, ulceration occurred more frequently in the 19 over-diagnosed lesions (pathologically proven to be T1a) than in the remaining lesions (47.4% vs. 10.5%, P < 0.05). Among 15 surgically resected lesions, three (20%) were diagnosed as T1b by EUS, but were considered to have endured unnecessary resection with the pathological diagnosis of T1a. [Conclusions] In EGCs, which were difficult to predict their invasion depth, EUS was especially useful for detecting T1a. The appropriateness of selecting ESD for some lesions diagnosed as T1b by EUS was also indicated.