Japan Digestive Disease Week 2021
International Poster Session 3 (JDDW)
November 5, 9:30–10:10, Room 16 (Kobe International Exhibition Hall No.3 Building Digital Poster Venue)
IP-11_H
Possible prediction of functional cure by HBV core mutations in patients with chronic hepatitis B
- 1
- Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine
【Aim】Predictors of functional cure (FC) become more important in patients with chronic hepatitis B. We have previously reported that hepatitis B core region mutation (I97L) is an important predictor of hepatitis subsidence. In the present study, we investigated whether I97L could be a predictor of FC.
【Methods】We identified I97 wild type (wt) or I97L in a cohort of patients with chronic hepatitis B to investigate the characteristics of patients with a good course leading to FC. We also analyzed factors related to FC by Cox's proportional hazards analysis.【Results】The baseline characteristic of 159 cases of chronic hepatitis B showed a median age of 42 years, 57 cases had I97L, 102 cases had I97wt.HBs antigen loss was seen in 15 of 159 cases and I97L mutation was seen in 11 cases (73.3%). HBV DNA of patients with FC was significantly lower than those in non-FC cases (P=0.003). HBs antigen level of FC was significantly lower than those in non-FC (P=0.0001).In Cox proportional hazards analysis, HBs antigen level and I97L mutation were significant factors involved in FC (P=0.002, P=0.033 Exp 0.29, 6.89, respectively).【Conclusion】I97L mutation would be a possible predictor of FC, along with HBs antigen levels.
【Methods】We identified I97 wild type (wt) or I97L in a cohort of patients with chronic hepatitis B to investigate the characteristics of patients with a good course leading to FC. We also analyzed factors related to FC by Cox's proportional hazards analysis.【Results】The baseline characteristic of 159 cases of chronic hepatitis B showed a median age of 42 years, 57 cases had I97L, 102 cases had I97wt.HBs antigen loss was seen in 15 of 159 cases and I97L mutation was seen in 11 cases (73.3%). HBV DNA of patients with FC was significantly lower than those in non-FC cases (P=0.003). HBs antigen level of FC was significantly lower than those in non-FC (P=0.0001).In Cox proportional hazards analysis, HBs antigen level and I97L mutation were significant factors involved in FC (P=0.002, P=0.033 Exp 0.29, 6.89, respectively).【Conclusion】I97L mutation would be a possible predictor of FC, along with HBs antigen levels.
- Index Term 1: hepatitis B
- Index Term 2: functional cure