International Poster Session 7 (JDDW)
November 5, 15:36–16:08, Room 16 (Kobe International Exhibition Hall No.3 Building Digital Poster Venue)
IP-35_E

Contamination rates in patient-ready gastrointestinal endoscopes: A systematic review and meta-analysis based on Asian data.

Sara Larsen1
Co-authors: Nikolaj Birk Larsen2, Naoko Katagiri3, Lotte Klinten Ockert1,4, Sven Adamsen1,4
1
Ambu A/S, Denmark
2
Department of Health Science and Technology, Aalborg University
3
Ambu K.K., Japan
4
Digestive Disease Center, Bispebjerg Hospital, University of Copenhagen
Aim: The elevator has been suggested as being a key factor in multiple outbreaks associated with contaminated reusable duodenoscopes. The outbreaks have led to increased focus on contamination of the elevator. However,  studies have documented microbes in endoscopes without an elevator. We aimed to estimate the contamination rate of GI endoscopes beyond the elevator based on available data from Asia.
Methods: We searched PubMed, Web of Science and Embase, from 1 January 2010 until 10 October 2020. A random-effects model based on the proportion distribution was used to calculate the total weighted contamination rate of patient-ready GI endoscopes beyond the elevator. Heterogeneity between the included studies was analysed using the inconsistency index (I2) statistics. Publication bias was assessed using funnel plot and Egger’s regression test.
Results: We identified five studies conducted in Asia (two from China and three from Taiwan) including 393 positive cultures from a total of 1,076 samples. The total weighted contamination rate was 36.44% (95% Cl: 13.06% - 59.81%). I2 indicated high heterogeneity (98.4%). Egger’s regression test was not significant for publication bias (p=0.390).  
Conclusions: Our findings highlight that the elevator is not the only obstacle when reprocessing reusable GI endoscopes.
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