Prevention of post-esophageal ESD stricture by sprayable, highly-adhesive hydrophobized gelatin microparticles Poster Award

Background Endoscopic submucosal dissection (ESD) is now used worldwide. However, complications, including postoperative esophageal stricture, have not improved. Herein, we reported a sprayable wound dressing comprising multifunctional hydrophobized microparticles (hMPs), which show strong tissue adhesion and effectively suppress submucosal inflammation post-ESD gastric ulcers in miniature swine.
Objective To determine the efficacy of hMPs in preventing postoperative esophageal ESD stricture.
Methods Circumferential esophageal ESD was conducted on a miniature swine. We classified the subjects into the following two groups: those who had been sprayed with and without hMPs. hMPs were sprayed on the sprayed group on days 0, 3, and 7. The nonsprayed group had undergone endoscopy on the same days. We compared the esophageal stricture rate, submucosal inflammatory cell infiltration, and thickening of the muscular layer in both groups on Day 14.
Results Endoscopic passage was impossible in both groups. The esophageal stricture rate was lower in the sprayed group than in the control group after sacrificing on Day 14. In addition, inflammatory cell infiltration in the submucosal layer and thickening of the muscular layer was suppressed in the sprayed group compared to the control group.
Conclusion hMPs may prevent the stricture of postoperative esophageal ESD by suppressing inflammatory cell infiltration in the submucosa and thickening the muscular layer.