Japan Digestive Disease Week 2022
International Poster Session5 (JDDW)
October 28, 10:42–11:22, Room 15 (Marine Messe Fukuoka Arena Digital Poster Session)
IP-25_S
The role of lung metastases on survival in stage IV colorectal cancer with multi-organ metastases
- 1
- Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine
Introduction
We investigated the impact of metastatic sites on survival in stage IV CRC with multi-organ (> 2) metastases.
Methods
Of 250 patients with stage IV CRC between 2008 and 2020, 78 patients with multi-organ metastases were included in this study.
Results
Of 78 patients, the number of the metastatic sites was 2 in 49 patients, whereas it was 3 or more in 29 patients. Curative resection was achieved in 11 patients (13.9%). Although patients had a similar OS with or without liver, extra-regional lymph node, or peritoneal dissemination, the OS in patients with lung metastasis was significantly better than those without (3-year OS: 28.2% vs. 0%, p = 0.044). Patients with lung metastases had 3 or more metastatic sites (45.5% vs. 23.5%, p = 0.045) and undifferentiated histologic type (9.1% vs. 35.3%, p = 0.009) more frequently, but had peritoneal dissemination less frequently (31.0% vs. 69.0%, p < 0.001) compared to those without lung metastases. The curative resection rate was similar between patients with and without lung metastases.
Conclusions
In stage IV CRC with multi-organ metastasis, patients with lung metastasis might have potential for longer OS.
We investigated the impact of metastatic sites on survival in stage IV CRC with multi-organ (> 2) metastases.
Methods
Of 250 patients with stage IV CRC between 2008 and 2020, 78 patients with multi-organ metastases were included in this study.
Results
Of 78 patients, the number of the metastatic sites was 2 in 49 patients, whereas it was 3 or more in 29 patients. Curative resection was achieved in 11 patients (13.9%). Although patients had a similar OS with or without liver, extra-regional lymph node, or peritoneal dissemination, the OS in patients with lung metastasis was significantly better than those without (3-year OS: 28.2% vs. 0%, p = 0.044). Patients with lung metastases had 3 or more metastatic sites (45.5% vs. 23.5%, p = 0.045) and undifferentiated histologic type (9.1% vs. 35.3%, p = 0.009) more frequently, but had peritoneal dissemination less frequently (31.0% vs. 69.0%, p < 0.001) compared to those without lung metastases. The curative resection rate was similar between patients with and without lung metastases.
Conclusions
In stage IV CRC with multi-organ metastasis, patients with lung metastasis might have potential for longer OS.
- Index Term 1: StageIV colorectal cancer
- Index Term 2: Lung metastasis