Japan Digestive Disease Week 2022
International Session (Panel Discussion)1 (JSGE, JGES, JSGS, JSGCS)
October 29, 14:30–17:00, Room 8 (Fukuoka International Congress Center 411+412)
IS-PD1-6_G
Clinical significance of focal pancreatic parenchymal atrophy detected before pancreatic cancers developed
- 1
- Department of Gastroenterology, Sendai City Medical Center
BACKGROUND AND AIM
Focal pancreatic parenchymal atrophy (FPPA) has been known an indicator of early pancreatic cancer (PC). We clarified 1) the detection rate of FPPA before PCs developed, 2) the duration from the detection of FPPAs to the development of PCs.
PATIENTS AND METODS
This study included 61 patients with PCs who underwent CT or MRI more than 2 months before the histological confirmation of PCs(2003.4-2021.7; median age, 75 years; males, n = 34). FPPA was defined as a focal depression of the pancreatic parenchymal edge > 5mm.
RESULTS
1) During a median surveillance period of 38 months before PCs developed (range: 4-192), FPPA was detected for 41% of patients (25/61; head, n = 10; body/tail, n = 15). Other imaging findings such as main pancreatic duct (MPD) stricture, MPD dilation, and pancreatic cysts, were detected for 38%, 43%, and 33%, and only FPPA was detected for 20% of patients. 2) For 22 patients with FPPA, the median duration from the detection of FPPA to the development of PCs was 32 months (range: 4-124), and the progression of FPPA was observed for 68% of patients with FPPA.
CONCLUSION
FPPA may be a promising indicator of latent PCs because FPPAs could be detected in 40% of patients since about 30 month before PCs become visible.
Focal pancreatic parenchymal atrophy (FPPA) has been known an indicator of early pancreatic cancer (PC). We clarified 1) the detection rate of FPPA before PCs developed, 2) the duration from the detection of FPPAs to the development of PCs.
PATIENTS AND METODS
This study included 61 patients with PCs who underwent CT or MRI more than 2 months before the histological confirmation of PCs(2003.4-2021.7; median age, 75 years; males, n = 34). FPPA was defined as a focal depression of the pancreatic parenchymal edge > 5mm.
RESULTS
1) During a median surveillance period of 38 months before PCs developed (range: 4-192), FPPA was detected for 41% of patients (25/61; head, n = 10; body/tail, n = 15). Other imaging findings such as main pancreatic duct (MPD) stricture, MPD dilation, and pancreatic cysts, were detected for 38%, 43%, and 33%, and only FPPA was detected for 20% of patients. 2) For 22 patients with FPPA, the median duration from the detection of FPPA to the development of PCs was 32 months (range: 4-124), and the progression of FPPA was observed for 68% of patients with FPPA.
CONCLUSION
FPPA may be a promising indicator of latent PCs because FPPAs could be detected in 40% of patients since about 30 month before PCs become visible.
- Index Term 1: focal pancreatic parenchymal atrophy
- Index Term 2: pancreatic cancer