Examination of prognostic risk factors for colorectal cancer patients with liver metastasis and future strategies in our department

[Aim] We retrospectively examined the prognostic risk factors for patients who underwent hepatectomy for colorectal cancer liver metastasis (LM). [Methods] From January 2010 to December 2020, 83 patients, excluding R1 / 2 cases, were evaluated for recurrence and survival risk factors by Cox proportional hazard model. [Results] Patient’s characteristics: Age: 66 (34-83), M / F: 46/37, Primary lesion: right / left =29/54, pT4 was 20 and pN positive was 59 cases. Regarding LM, 36 cases (43.4%) had a tumor of 3 cm or more, 24 cases (28.9%) had 3 or more tumors, and 25 cases (30.1%). Nine cases had extrahepatic metastasis. Simultaneity / asynchrony: 70/13. NAC was given to 52 patients (62.7%) before hepatectomy. 50 cases (60.2%) of recurrence due to distant metastasis, and the median RFS was 9 months. 5-year survival rate was 60.6%. High CA19-9, 3 or more LM, H2 / 3 in univariate analysis, and 3 or more LM in multivariate analysis (HR = 1.57, 95% CI: 1.01-3.40, p=0.047) was an independent risk factor of recurrence. Similarly, the number of 3 or more LM was an independent risk factor of survival. (HR = 3.08, 95% CI: 1.40-6.88, p=0.006) [Future prospects] We are currently planning a clinical study using FOLFOXIRI as a NAC for hepatectomy.