The location of Barrett's adenocarcinoma is related to the esophageal reflux factor and the baseline value of MII Young Award

AIM
We aimed to clarify the relationship between Barrett's adenocarcinoma (BA) location and reflux factors and mucosal injury using 24hr MII-pH (MII).
METHODS
We examined MII and mean nocturnal baseline value (MNBI) which suggests mucosal injury for 56 patients with superficial BA. We classified them into EGJ-group (lesions adjacent to EGJ) and nonEGJ-group (lesions apart from EGJ), and into 0-3 and 4-11 o'clock group according to the circumference.
RESULTS
(1) There were 35 patients in EGJ-group. AET and bolus exposure of nonEGJ-group (12.9%,7.1) were higher than those of EGJ-group (2.1,1.8) (p〈0.05). MNBI of 3, 5, and 7cm above LES in nonEGJ-group (305Ω,511,and 808) were lower than those of EGJ group (1850,1785,and 1974) (p〈0.05).
(2) There were 42 patients in 0-3 o'clock group. AET and bolus exposure of 4-11 o'clock group (10.2,13.7) were higher than those of 0-3 o'clock group (3.5,2.6) (p〈0.05). MNBI of 3, 5, and 7cm above LES in 4-11 o'clock group (295,396,and 526) were lower than those of 0-3 o'clock group (1283,1641,and 1807) (p〈0.05).
CONCLUSION
BA location is related to the degree of esophageal reflux and mucosal injury.