Liver cirrhosis is progressive disease. Now we can treat HBV and HCV related liver cirrhosis, but the therapy to cure liver fibrosis itself is still unmet demand. Basic study to understand the mechanism of liver fibrosis is proceeding. Concerning with evaluation method to analyze liver fibrosis (biomarker and elastography) were also progressed in clinical field. On the other hands, new strategy using drug, cell, gene and exosome is developing. To develop a next generation therapy for liver cirrhosis in clinical, adequate design of clinical study and trial is needed. In this symposium we will discuss the current status of diagnosis and therapy for liver cirrhosis and new findings of liver cirrhosis therapy and sum up the strategy of next step.