Professor of Pathology, Medicine, and Oncology

EDUCATION/TRAINING

Trinity College Dublin, Dublin Ireland B.A.   1988   Pre-Medical Science
Trinity College Dublin, Dublin Ireland M.B.   1988   Medicine
Trinity College Dublin, Dublin Ireland M.D.   1997   Doctorate

Personal Statement

I have directed a pancreatic cancer early detection research lab since 1999. The goal of my research is to improve the outcome of patients with pancreatic cancer and those at risk of developing this disease. Much of our work is focused on translational research evaluating markers and marker technologies that can help screen patients with an increased risk of developing pancreatic cancer. I lead the Cancer of the Pancreas screening-5 (CAPS5) study. CAPS5 is a multi-center study evaluating the utility of pancreatic screening in different risk groups and evaluating circulating and other markers of pancreatic neoplasia in patients with a familial/inherited susceptibility to pancreatic cancer and those with pancreatic cancer and comparing marker performance in these patients to individuals with chronic pancreatitis, pancreatic cysts, and normal pancreata. I maintain a large repository of specimens from cases and controls with and without pancreatic disease. I have been an NIH-funded investigator continuously since 2000. I have helped identify the main genetic alterations responsible for the progression of PanINs and IPMNs to invasive pancreatic cancer and some of the genes responsible for pancreatic cancer susceptibility. I have published over 350 peer-reviewed papers, over 100 as first or last author, almost all related to pancreatic cancer and have a Google h-index of 137. I am the PI of a Pancreatic Cancer Early Detection Consortium U01 grant that supports the CAPS multi-center and our early detection efforts.

Positions and Honors

Positions and Employment

7/08 - Present	Professor of Pathology, Medicine and Oncology, Division of GI/Hepatology, JHU
2003 - 2008	Associate Professor of Pathology, Medicine, Oncology, Division of GI/Hepatology, JHU
2000 - 2003	Assistant Professor of Medicine, Division of Gastroenterology/Hepatology, JHU
2000 - Present	Attending in Medicine, Division of Gastroenterology/Hepatology, Johns Hopkins Hospital
1999 - Present	Director of the Pancreatic Cancer Early Detection Laboratory, JHU
1999 - 2003	Assistant Professor of Pathology and Oncology, Johns Hopkins University
1999	Instructor in Pathology and Oncology, The Johns Hopkins Medical Institutions
1998	Research Associate, Department of Oncology, Johns Hopkins University
1995 - 1998	Research Fellow, Dept. of Pathology, Johns Hopkins University,
1992 - 1995	Lecturer in Clinical Medicine, Trinity College Dublin
1991 - 1995	Clinical Fellow in Gastroenterology and Internal Medicine, St. James’ Hospital, Dublin
1988 - 1991	Resident in Internal Medicine, St. James’ Hospital, Dublin