International Session（Symposium）2(JSGS・JSGE・JGES)
Fri. November 3rd   14:00 - 17:00   Room 11: Portopia Hotel South Wing Topaz
IS-S2-5_S
 Significance of induction DCF therapy followed by conversion surgery for locally advanced unresectable esophageal squamous cell carcinoma
Junya Oguma1, Koshiro Ishiyama1, Hiroyuki Daiko1
1Department of Esophageal Surgery, National Cancer Center Hospital
Introduction: Conversion surgery, which is defined as local treatments aimed at curing the disease after initial treatment, is recently well performed because of the development of management for induction DCF therapy. However, short and long-term outcomes of induction DCF therapy followed by conversion surgery have not been well evaluated yet.
The aim of the present study is to evaluate the significance of induction DCF therapy followed by conversion surgery for locally advanced unresectable ESCC. Results: Induction DCF therapy was performed for 78 patients with locally advanced unresectable ESCC from 2016 to 2021 in our institute. Among these, conversion esophagectomy was undergone for 60 patients (77%) and furthermore, pathological R0 resection was achieved for 46 patients (59%). Short and long-term outcomes were compared between these 46 patients (cT3br/T4b group) and 65 patients with cT3 resectable ESCC who received neoadjuvant DCF therapy followed by esophagectomy (R0 resection) during the same period (cT3 group). There were not significant differences of short-term outcomes between two groups. These were not also differences of 5yOS rate (0.654 vs. 0.743) and 5yRFS rate (0.592 vs. 0.627) between two groups (p=0.695, p=0.665, respectively). Conclusion: If R0 resection as a conversion surgery was achieved for patients with locally advanced unresectable ESCC, short and long-term outcomes after conversion surgery were not inferior to these outcomes of surgery for patients with cT3 resectable ESCC.
Index Term 1: esophageal cancer
Index Term 2: conversion surgery
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