International Session（Workshop）1(JSGE・JSH・JSGCS)
Thu. November 2nd   14:30 - 17:00   Room 11: Portopia Hotel South Wing Topaz
IS-W1-Keynote Lecture1
 Molecular mechanisms and therapeutic targeting of Hepatitis B
Yuchen Xia
Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University
Chronic hepatitis B virus (HBV) infection remains a major global health problem. Despite the availability of an effective vaccine, current treatment options for chronically infected patients are limited. Molecular mechanisms involved in HBV replication and pathogenesis are complicated, including HBV entry into hepatocytes, DNA replication by reverse transcription, HBV mRNA transcription and translation, and immune system evasion. New insights into these mechanisms have fueled the development of promising antiviral therapies, including entecavir, tenofovir, viral entry/maturation inhibitors, immunomodulatory agents, RNA interference and gene therapy targeting cccDNA.
Here, we aim to provide an overview of the HBV life cycle and summarize the state-of-the-art knowledge of the molecular mechanisms involved in HBV life cycle. We will also discuss current treatment options as well as promising antiviral strategies under development for combating chronic HBV infection. A combination of therapies targeting multiple steps of the HBV life cycle may lead to a functional cure for chronic hepatitis B. A better understanding of the virus-host interactions will continue to be critical for developing new therapeutics to target currently unmet needs in HBV management. Continued progress in both preclinical and clinical research will be crucial to advancing HBV treatment to achieve higher cure rates with lower toxicity.
Index Term 1: virus life cycle
Index Term 2: antiviral target
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