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International Session（Workshop）1(JSGE・JSH)
Fri. November 1st   15:30 - 17:00   Room 9: Portopia Hotel Main Building Kairaku 3
IS-W1-4_H
 Factors associated with prognosis after viral eradication in hepatitis C virus patients treated with direct-acting antiviral
Yuki Tahata1, Hayato Hikita1, Tetsuo Takehara1
1Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine
Background: Sustained virologic response (SVR) could be achieved by direct-acting antiviral (DAA) in almost all hepatitis C virus (HCV) patients, but factors associated with prognosis after SVR are unclear.
Methods: A total of 3,049 HCV patients without hepatocellular carcinoma (HCC) history who started DAA and achieved SVR24 were included. Liver-related death was defined as HCC, intrahepatic cholangiocarcinoma, varix rupture and liver failure. Factors associated with liver-related and non-liver-related death were examined.
Results: The median age was 69 years, and 15% of patients had liver cirrhosis. During 58.0 months from SVR, 23 patients died of liver-related causes, and 133 patients died of non-liver-related causes. Liver-related and non-liver-related mortality at 7 years were 1.2% and 8.1%, respectively. In multivariate analysis, older age (p=0.003), liver cirrhosis (p=0.033), lower platelet count at SVR (p=0.002) and higher gamma-glutamyl transpeptidase (GGT) level at SVR (p<0.001) were significantly associated with liver-related mortality, and older age (p<0.001), male (p<0.001), diabetes mellitus (p=0.018) and lower albumin level at SVR (p<0.001) were significantly associated with non-liver-related mortality.
Conclusions: Among SVR patients without HCC history, 85% of deaths were non-liver-related cause. Older age, liver cirrhosis, lower platelet count at SVR and higher GGT level at SVR were associated with liver-related death, and older age, male, diabetes mellitus and lower albumin level at SVR were associated with non-liver-related death.
Index Term 1: DAA
Index Term 2: prognosis
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