| International Session（Workshop）1(JSGE・JSH) |
| Fri. November 1st 15:30 - 17:00 Room 9: Portopia Hotel Main Building Kairaku 3 |
| Clinical impact of HCV eradication on short and long-term outcome after curative hepatic resection | |||
| Hirohisa Okabe1, Hiromitsu Hayashi1, Hideo Baba1 | |||
| 1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University | |||
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| Background: The aim of this study is to clarify the clinical impact of HCV eradication on short- and long-term outcome after curative hepatic resection in such patients. Methods: Four hundred and ninety-six HCC patients with chronic HCV infection receiving curative hepatic resection were enrolled in this study. A short- and long-term outcome after surgery were compared using propensity score matching analysis. Results: After matching, there were no statistical difference in background characteristics such as liver function, surgical procedures, and oncological features between non-SVR group (n = 116) and SVR group (n = 116). Although pathological fibrosis staging defined by New Inuyama classification were comparable between groups, hepatitis activity grading in non-SVR group (n = 116) was significantly worse than that in SVR-group (n = 116) (p < 0.0001). Non-SVR group showed higher operation time (p = 0.0485), longer postoperative in-hospital days (p = 0.0014), and higher total bilirubin value at postoperative day 5 which is reported to be an indicator of postoperative liver failure (p = 0.00196). Cumulative overall survival after surgery was comparable between groups. Conclusion: Eradication of HCV provides significant improvement of pathological activity of hepatitis, and might cause improved short-term outcome after hepatic resection. Long-term outcomes are comparable between groups. |
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Index Term 1: Sustained virologic response Index Term 2: hepatocellular carcinoma |
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