| International Session（Workshop）3(JGES・JSGE・JSGS) |
| Sat. November 2nd 9:00 - 12:00 Room 4: Portopia Hotel South Wing Portopia Hall |
Development of endoscopic novel sheet made of bioabsorbable material and hydrogel
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| Masayoshi Ono1, Shunsuke Ohnishi2, Naoya Sakamoto1 | |||
| 1Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, 2Molecular and Cellular Medicine, Hokkaido University Faculty of Pharmaceutical Sciences | |||
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| [Background/Aims] We aim to create an endoscopic bandage utilizing a novel bioabsorbable material and hydrogel to simplify wound coverage during ESD. This addresses challenges such as difficulty, time consumption, and cost associated with traditional methods involving wound sutures and PGA sheets, which are not widely adopted. [Methods] We determined the size and shape of the bioabsorbable material and suitable base materials for the hydrogel, prioritizing those easily deployable through the endoscope's forceps port, compatible with the sheet, and clinically tested in humans. Animal experiments involved performing stomach or colon ESD on pigs, inducing a perforation of 5-8 mm. Wounds were protected using the sheet and hydrogel, with endoscopic assessment on day 7 or day 14, followed by pathological evaluation upon sacrifice. Control groups receiving no treatment after ESD were also included. [Results] A 15 mm circular sheet, composed of a blend of lactic acid and caprolactone copolymer along with a PGA sheet, proved easy to use during endoscopy. The hydrogel, crafted from sodium alginate and calcium chloride, exhibited superior adhesion compared to fibrin glue. Following ESD, the perforation site was successfully closed, resulting in reduced wound size compared to the untreated group. [Conclusions] The new bioabsorbable materials and hydrogels demonstrated potential for closing perforations and facilitating wound regeneration. |
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Index Term 1: ESD Index Term 2: Bioabsorbable material |
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