| Strategic International Session1（W）(JGES・JSGE・JSGCS) |
| Thu. October 31st 14:30 - 17:00 Room 9: Portopia Hotel Main Building Kairaku 3 |
| Advancing Endoscopic Anti-reflux Therapy: Anti-reflux Mucoplasty for PPI Refractory/Dependent Gastro-esophageal Reflux Disease | |||
| Kazuki Yamamoto1, Yuto Shimamura1, Haruhiro Inoue1 | |||
| 1Digestive Diseases Center, Showa University Koto Toyosu Hospital | |||
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| Background: Anti-reflux mucosectomy (ARMS) and anti-reflux mucosal ablation (ARMA) aimed at managing PPI/PCAB refractory/dependent GERD. Despite their documented effectiveness, relying solely on natural healing for ulcer scar contraction carries risks of stricture and bleeding. To address this concern, we introduced anti-reflux mucoplasty (ARM-P), which involves the immediate closure of mucosal defects following mucosectomy. This study aims to evaluate the safety, feasibility, and efficacy of ARM-P. Methods: A retrospective single-center study analyzed prospectively collected data from October 2022 to January 2024. The study evaluated various aspects including ARM-P's technical success, pre- and post-procedure GERD-Health Related Quality of Life Questionnaire (GERD-HRQL), GerdQ, and Frequency Scale for the Symptoms of GERD (FSSG) scores, alongside the rate of discontinuation of PPI medication. Results: Thirty-nine patients (mean age: 51.9 years, SD±17.1) underwent ARM-P, achieving 100% technical success in a median procedure duration of 68 minutes (IQR: 25-45). Following ARM-P, 51.3% (20/39) ceased PPI medication, while 17.9% (7/39) halved their PPI dose. Median GERD-HRQL score improved significantly from 24.5 (IQR: 0-46) to 9.5 (IQR: 0-39) (P <0.001), GERDQ score decreased from 8 (IQR: 2-15) to 7 (IQR: 1-13) (P = 0.0027), and FSSG score reduced from 27.5 (IQR: 2-46) to 11 (IQR: 0-40) (P <0.001). No postoperative bleeding or stenosis occurred. Conclusions: This study highlights the procedural safety, technical feasibility, and short-term efficacy of ARM-P. |
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Index Term 1: GERD Index Term 2: endoscopic anti-reflux therapies |
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