| Strategic International Session1（W）(JGES・JSGE・JSGCS) |
| Thu. October 31st 14:30 - 17:00 Room 9: Portopia Hotel Main Building Kairaku 3 |
Pathogenic helper Th2 cells remain within the esophageal mucosa of EoE in even remission phase
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| Akane Kurosugi1,2, Kiyoshi Hirahara2, Naoya Kato1 | |||
| 1Department of Gastroenterology, Graduate School of Medicine, Chiba University, 2Department of Immunology, Graduate School of Medicine, Chiba University | |||
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| Background: Eosinophilic esophagitis (EoE) frequently recurs when treatment is interrupted, and the mechanism has not been elucidated. We previously reported that pathogenic helper Th2 (Tpath2) cells in the esophageal mucosa of patients with EoE were responsible for eosinophilic inflammation by producing large amount of Th2 cytokines; Herein, we examined the involvement of Tpath2 cells in the refractory of EoE with endoscopically obtained specimen. Methods: We collected esophageal mucosa biopsies regardless of the endoscopic findings from 11 patients (generally 2 specimens from 5cm and 15cm oral side of esophagogastric junction respectively) diagnosed with EoE and measured the frequency of eosinophils and Tpath2 cells by flowcytometry. Patient's medical history and disease course were also reviewed. Results: Of the 11 patients, 6 (54.5%) were in remission from EoE and 5 (45.5%) had active disease; Notably abnormal distribution of Tpath2 cells within the esophageal mucosa of the patients in remission were observed to the same levels in those with active disease. In remission cases, Tpath2 cells were detected an average of 37.5 months after remission. Two patients who were absence of treatment relapsed EoE in the subsequent disease course. Conclusion: Tpath2 cells remain within the esophageal mucosa of patients with EoE for a long time regardless of eosinophil control. |
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Index Term 1: Eosinophilic esophagitis Index Term 2: Pathogenic helper Th2 cells |
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