| Strategic International Session1（W）(JGES・JSGE・JSGCS) |
| Thu. October 31st 14:30 - 17:00 Room 9: Portopia Hotel Main Building Kairaku 3 |
| Identification of iron components in gastric black spots by NanoSuit-CLEM analysis | |||
| Kiichi Sugiura1, Hideya Kawasaki2, Moriya Iwaizumi3 | |||
| 1First Department of Medicine, Hamamatsu University School of Medicine, 2Institute for NanoSuit Research, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, 3Department of Laboratory Medicine, Hamamatsu University School of Medicine | |||
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| Objectives: This study investigates black spots (BSs), lentiginous lesions found in the gastric body and fundus during upper gastrointestinal endoscopy, mainly reported in patients undergoing Helicobacter pylori (H. pylori) eradication. It aims to delineate the clinicopathological characteristics of BSs, analyze patient demographics, and apply the NanoSuit-CLEM Method combined with SEM-EDS for elemental analysis. Methods: We retrospectively reviewed medical records of patients who underwent upper gastrointestinal endoscopy from 2017 to 2022, collecting data on age, medication use, blood tests, and H. pylori status. Univariate and multivariate analyses identified BS risk factors. Pathological specimens from BS patients underwent elemental analysis using NanoSuit-CLEM with SEM-EDS. Results: Among 6,778 patients, risk factors for BSs included older age and the use of proton pump inhibitors, statins, corticosteroids, and antithrombotic drugs. BS presence correlated with greater gastric atrophy and lesser active H. pylori infection. NanoSuit-CLEM revealed specific iron deposition at BS sites. Conclusions: BSs may signify the absence of active H. pylori infection. The identification of iron deposition within BSs provides new insights into their potential causes, enhancing our understanding of BS etiology and the mechanisms of their formation. |
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Index Term 1: black spots Index Term 2: gastric pathology |
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