| International Session（Symposium）3(JSGE・JSH・JSGS・JSGCS) |
| Fri. November 1st 9:30 - 11:30 Room 4: Portopia Hotel South Wing Portopia Hall |
| Elucidation free amino acid profile of peripheral blood in MASLD | |||
| Eiji Kakazu1, Masaaki Mino1, Tatsuya Kanto1 | |||
| 1Department of Liver Diseases, The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine | |||
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| Background The changes in plasma free amino acids (FAAs) associated with MASLD based on cardiometabolic criteria (CC) are unknown. Methods We analyzed the plasma FAAs data of 28,823 general adults from a biobank in Japan (ToMMO) and 310 patients with MASLD. We divided the subjects into five groups based on the presence of steatotsis (SLD), conformity to CC, and alcohol consumption: MASLD, MetALD, CC-SLD+, CC+SLD-, and CC-SLD-. Results After exclusion criteria, the final case numbers were MASLD (712), MetALD (440), CC-SLD+ (68), CC-SLD- (2,136), and CC+SLD- (9,968). Of the 20 types of FAAs, 16 showed a significant increase in the CC+SLD- compared to the CC-SLD-, with the number of CC met. Of these 16 FAAs, 10 showed a further increase in MASLD. Conversely, 5 FAAs showed significant decrease or no change in MASLD compared to CC-SLD-, with 3 of these FAAs showing a significant decrease with the steatosis grade in liver of MASLD patients. Regarding changes associated with the liver fibrosis, BCAAs were highest at F2 and then decreased, while aromatic amino acids showed a significant increase with the F grade. Discussion & Conclusion Metabolic abnormalities related insulin resistance increased most of FAAs, which was more pronounced in MASLD, while some FAAs decreased. The names of the individual FAAs will be disclosed on the presentation. |
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Index Term 1: MASH Index Term 2: Carfiometabolic criteria |
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