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Steatotic liver disease without habitual alcohol drinking and structural brain imaging in community-dwelling older subjects: A-city population-based prospective cohort study
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Maiko Nagaoka1,
Katsuya Nagaoka2,
Yasuhito Tanaka2 |
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1Health Care Center, Kumamoto University, 2Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University |
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| Background: A cohort study was a prospective population-based study of 1,577 residents aged 65 years or older in city A from 2016 to 2017 to investigate dementia and depression. We recently reported that high FIB-4 with Metabolic dysfunction-associated steatotic liver disease (MASLD) are associated with the risk of dementia. This study examined the association between brain structural MRI measures and steatotic liver disease (SLD). Methods: Subjects were 1,448 participants of the A cohort who had no missing data values. Those who rarely drank or had stopped drinking for more than 5 years were defined as "light drinkers". Fatty liver index (FLI) ≥30 was classified as having SLD. Brain MRI images were subjected to area segmentation and each volume was measured. The study has been approved by the Ethics Committee of K University. Results: Out of 1,448 subjects, 885 were light drinkers, 377 with SLD and 366 with MASLD. Among light drinkers, SLD had significantly reduced volume of regions involved in event memory compared to non-SLD. (reduction rate: hippocampus 1.78%/amygdala 2.12%), Among MASLD, FIB4 ≥2.67 was also significantly reduced in these regions compared to FIB4<2.67 (5.64% and 5.62% respectively). Conclusions: Elderly people with high FIB4-MASLD may be at risk for volume reduction in event memory-related brain regions. |
Index Term 1: MASLD
Index Term 2: Brain MRI
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