| International Session（Symposium）3(JSGE・JSH・JSGS・JSGCS) |
| Fri. November 1st 9:30 - 11:30 Room 4: Portopia Hotel South Wing Portopia Hall |
| Long-term Impact of Bariatric Surgery (BS) on Vascular Outcomes in Adult Patients with Obesity, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Type 2 Diabetes (T2D) | |||
| Arunkumar Krishnan1, Aldanah M Althwanay3, Saleh A Alqahtani1,2 | |||
| 1Johns Hopkins University, 2King Faisal Specialist Hospital & Research Center, 3University of Maryland Medical Center | |||
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| Aim: To explore the enduring effects of BS on macro and microvascular outcomes in patients with obesity, MASLD, and T2D compared to those undergoing nonsurgical care Methods: We included data from adult patients (aged >18 years) diagnosed with MASLD, T2D, and obesity from a global federated health research network. Bariatric surgery procedures included Roux-en-Y gastric bypass and sleeve gastrectomy. The primary outcomes examined were the incidence of macrovascular diseases, defined as the composite indicator of the first occurrence of heart failure, major adverse cardiovascular events (MACE), or cerebrovascular disease. Results: A total of 91922 patients were identified, and 2898 patients had a history of BS, with a median follow-up of 5.1 years. BS and non-surgical groups (2449 each) were propensity-matched. BS patients had a higher mean BMI. The risks of MACE (HR, 0.37), HF (HR, 0.43), and composite cerebrovascular diseases (HR, 0.65) were significantly lower for BS group. BS was also associated with a lower incidence of the secondary outcome of microvascular and all-cause mortality, consistent at follow-ups of 1, 3, 5, and 7 years. Conclusion: The findings of this study indicate BS, when compared to nonsurgical care, was linked to a notably reduced risk of both macro and microvascular outcomes in patients with MASLD, obesity, and T2D. |
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Index Term 1: Bariatric Surgery Index Term 2: MASLD |
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