| International Session（Panel Discussion）1(JSGE・JGES・JSGS) |
| Fri. November 1st 10:00 - 12:00 Room 7: Portopia Hotel South Wing Ohwada C |
Evaluation of Serum Leucine-Rich α2-Glycoprotein Levels in Racial Differences
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| Yasuhiro Aoki1,2, Yohei Mikami1, Takanori Kanai1 | |||
| 1Department of Gastroenterology and Hepatology, Keio University School of Medicine, 2Department of Gastroenterology, National Hospital Organization Tokyo Medical Center | |||
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| Background: Serum leucine-rich α2-glycoprotein (LRG) serves as a biomarker for assessing disease activity in inflammatory bowel disease (IBD) among Japanese patients. The study aimed to identify factors associated with LRG levels and expand the applicability of LRG for monitoring disease activity across racial groups. Methods: A retrospective study was conducted on all IBD patients with serum LRG levels measured at our hospital from July 2020 to November 2023. We analyzed the correlation between LRG and various parameters and evaluated LRG in relation to clinical and endoscopic activity in non-Japanese patients. Results: A total of 12,006 serum LRG measurements were analyzed in 1,791 ulcerative colitis patients, 747 Crohn´s disease patients, and 22 other patients, including 2,500 Japanese and 58 non-Japanese (26 Asian, 32 non-Asian) patients. LRG demonstrated a strong correlation with CRP (r=0.65) and Alb (r=-0.56). Notably, in non-Japanese patients, lower LRG levels were significantly associated with both endoscopic and clinical remission. The area under the curve (AUC) for LRG in predicting clinical and endoscopic remission in non-Japanese patients was 0.690 (95% CI=0.586-0.779) and 0.737 (95% CI=0.594-0.843), respectively, which was higher than that of CRP and Alb. Conclusion: LRG shows a correlation with CRP and Alb. It may serve as a useful biomarker across diverse racial populations for monitoring disease activity in IBD. |
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Index Term 1: LRG Index Term 2: IBD |
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