| International Session（Panel Discussion）1(JSGE・JGES・JSGS) |
| Fri. November 1st 10:00 - 12:00 Room 7: Portopia Hotel South Wing Ohwada C |
| Incidence of active lesions in CRP-negative Crohn´s disease patients based on MR enterography | |||
| Masatoshi Nakashima1, Masanori Imuta2, Yasuhito Tanaka1 | |||
| 1Department of Gastroenterology and Hepatology, Kumamoto University, 2Department of Diagnostic Radiology, Kumamoto University | |||
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| Background/Aim: Although the serum C-reactive protein (CRP) is useful biomarker for Crohn´s disease (CD) patients, negative for CRP is not sufficient as treatment target, and transmural healing is proposed as a long-term target in STRIDE-II. In this study, we investigated the prevalence of active lesions on MR enterography (MRE) in CRP-negative CD. Methods: CD patients performed MRE between January 2020 and February 2024 in our hospital were analyzed retrospectively. CRP-positive group and CRP-negative group were defined as CRP≥0.15mg/dl and CRP<0.15mg/dl respectively. The definitions of active lesions with the MRE were high signal in the T2 weighted image and contrast effect in the early phase. We assessed the frequency and characteristics of the CD patients with MRE active lesions in the CRP-negative group. Results: MRE was performed in 97 patients with CD. 40 patients (78%) were active in MRE among the CRP-positive group (N=51) and 28 patients (61%) were active in MRE among the CRP-negative group (N=46). In the CRP-negative group, MRE active patients had significantly higher CDAI scores (103 vs 66, p<0.05), higher LRG (13.5μg/ml vs 10.1μg/ml, p<0.01) and more endoscopically active ulcers (64% vs 22%, p<0.01) than the MRE inactive patients. Conclusion: Even in the CRP-negative patients, the high prevalence of active lesions was identified with MRE. Therefore, it is important to evaluate inflammation with multifaceted tools. |
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Index Term 1: Crohn’s disease Index Term 2: MR enterography |
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