| International Session（Panel Discussion）1(JSGE・JGES・JSGS) |
| Fri. November 1st 10:00 - 12:00 Room 7: Portopia Hotel South Wing Ohwada C |
| Risk factors for clinical relapse in patients with ulcerative colitis who are in clinical remission but with endoscopic activity | |||
| Ryosuke Horio1, Jun Kato1, Naoya Kato1 | |||
| 1Department of Gastroenterology, Graduate School of Medicine, Chiba University | |||
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| Background: Treatment strategy for patients with ulcerative colitis (UC) who are in clinical remission but had not achieved mucosal healing is not clear. This study aimed to identify risk factors of relapse in patients in clinical remission with endoscopic activity. Methods: Of the patients with UC who underwent colonoscopy, those in clinical remission with endoscopic activity were included. Characteristics were compared between patients who relapsed within two years after colonoscopy and those who did not. Risk factors contributing to clinical relapse were identified using a Cox proportional hazards regression model. Results: Total 142 patients in clinical remission with endoscopic activity of Mayo endoscopic subscore (MES) 1 or higher were regarded as eligible, and 33 (23%) relapsed during the observation period. Recent worsening of bowel symptoms was a significant risk factor for clinical relapse (hazard ratio [HR]: 3.02, 95% confidence interval [CI]: 1.34-6.84). This was particularly evident in patients with MES 2 (HR: 5.16, 95% CI 1.48-18.04), while in contrast, no risk factors were identified in patients with MES 1. Presence or absence of therapeutic intervention just after colonoscopy did not affect clinical relapse significantly. Conclusion: In UC patients in clinical remission with endoscopic activity, those who reported recent worsening in bowel symptoms should be a therapeutic target. |
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Index Term 1: ulcerative colitis Index Term 2: clinical relapse |
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