| International Session（Panel Discussion）1(JSGE・JGES・JSGS) |
| Fri. November 1st 10:00 - 12:00 Room 7: Portopia Hotel South Wing Ohwada C |
| Serum leucine-rich alpha-2 glycoprotein is an accurate marker for endoscopic and histological healing in ulcerative colitis | |||
| Ami Kawamoto1, Toshimitsu Fujii2, Ryuichi Okamoto2 | |||
| 1Endoscopic Unit, Institute of Science Tokyo, 2Department of Gastroenterology and Hepatology, Institute of Science Tokyo | |||
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| Background & Aim: Endoscopic and histological remission in ulcerative colitis (UC) lead to improved clinical outcomes in ulcerative colitis. We evaluated the accuracy of serum leucine-rich alpha-2 glycoprotein in monitoring for endoscopic and histological remission in UC patients. Method: 346 UC patients who underwent colonoscopy from July 2020 to September 2021 were included to compare the accuracy of CRP and LRG in detecting endoscopic and histological remission. ROC curve analyses were performed and their AUC values compared. Results: The median duration of disease for the 346 patients was 7 years, with 229 patients having pancolitis. The median values of CRP and LRG were 0.07mg/dL and 12.2μg/mL, respectively. Endoscopic remission, as defined as Mayo endoscopic sub-score of 0, was observed in 101 patients, and histological remission, as defined as Geboes score <3.1, was observed in 123 patients. The AUC values for CRP and LRG for detecting endoscopic remission were 0.67 and 0.73, respectively, whereas the AUC values for CRP and LRG for detecting histological remission were 0.59 and 0.75, respectively. The optimal cut-off value of LRG for detecting histological remission was 13.4 μg/mL, with a sensitivity of 83% and specificity of 57%. Conclusion: LRG is an accurate biomarker in detecting both endoscopic and histological remission in UC patients. |
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Index Term 1: Biomarker Index Term 2: Ulcerative Colitis |
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